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The most common adverse events were gastrointestinal in nature, including nausea, vomiting, diarrhea, constipation, and abdominal pain
Methods Cell Biol 80: 241260 CorteseJD,VoglinoAL,HackenbrockCR (1991) Ionic strength of the intermembrane space of intact mitochondria as estimated with fluoresceinBSA delivered by low pH fusion
IR impairs mitochondrial substrate utilization, shifting energy metabolism from glucose oxidation toward fatty acid oxidation, which increases ROS production and reduces oxidative phosphorylation efficiency
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