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GLP-1 medications work by mimicking natural incretin hormones to improve blood glucose control and reduce appetite Common side effects are gastrointestinal (nausea, vomiting, diarrhoea) rather than fluid retention Unlike thiazolidinediones, GLP-1 agonists are not associated with oedema as a recognised adverse effect Any unexplained swelling whilst taking GLP-1 medications requires medical assessment to exclude other causes Dehydration from gastrointestinal side effects is more common than fluid retention with GLP-1 therapy Table of Contents What Are GLP-1 Medications and How Do They Work

Though the loose, sagging skin around the jaw, cheeks, and neck of patients who have used Semaglutide to aid in their weight loss journey has been deemed Ozempic face, its an issue that has existed long before this medication hit the market

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Initial benefits like improved sleep quality and recovery can appear within 2-4 weeks

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Evaluated in preclinical models for receptor binding affinity and ligand-receptor kinetics