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This gastric emptying effect may diminish somewhat over time (tachyphylaxis) despite continued use

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Worsening heart failure alone was reduced to 8,0% versus 14,2% (HR 0,54)

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Thus, a systematic review and meta-analysis were conducted in this study in order to evaluate the efficacy and safety of combination therapy with SGLT-2i and GLP-1RA compared to monotherapy of each individual drug in patients with T2DM