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GPER modulates the balance between energy expenditure and thermogenesis by regulating the metabolic activities of BAT and white adipose tissue (WAT) (Fig

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The two peptides are clinically synergistic. No controlled combination trial was identified

Acute stress and large meals trigger GLP-1 in the brain to suppress appetite, preventing overeating

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Traditional weight loss approaches typically produce 5-10% reduction, often followed by significant regain within months