This helps explain why patients with extensive surgical trauma or prolonged ischemia often develop a systemic inflammatory response that parallels septic shock, even in the absence of infection ( Importantly, these pathways offer targets for intervention: blocking upstream mtDAMPs release or downstream receptors could blunt the harmful inflammation
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Kopchick is supported by the State of Ohio's Eminent Scholar Program, which includes a gift from Milton and Lawrence Goll, by AMVETS, and by NIH (P01AG031736)