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Consider increased clinical or laboratory monitoring when used concomitantly with other oral medications that have a narrow therapeutic index or that require clinical monitoring

Serotonin syndrome symptoms may include mental status changes (e.g., agitation, hallucinations, delirium, and coma), autonomic instability (e.g., tachycardia, labile blood pressure, dizziness, diaphoresis, flushing, hyperthermia), neuromuscular symptoms (e.g., tremor, rigidity, myoclonus, hyperreflexia, incoordination), seizures, and/or gastrointestinal symptoms (e.g., nausea, vomiting, diarrhea)

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Patent Protection: When a new drug is approved, the company that developed it is granted a patent

although the discoloration is benign, the combination may reduce dapsones antimicrobial effect and can stain clothing, so a minimum 30-minute interval between products-or the use of alternating morning/evening schedules-is advised

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