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Primary outcome measures include assessments of cognition, behavior, ADLs, general health status, A and tau biomarkers in CSF and plasma, MRI, EEG, and oxidative and transmitter biomarkers in the blood

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SAMe is essential for the production of glutathione, which is crucial for detoxification

Visual disturbances (including blue tinge to vision, increased sensitivity to light, or blurred vision) are common with sildenafil