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Ischemia, inflammation, and other pathological stimuli lead to intracellular calcium overload, which activates a cascade of signaling pathways that promote the conversion of pro-MMP-9 into its active proteolytic form (148)
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Higher costs and adverse effects were the most frequent reasons for discontinuation, as per clinical notes
Elife 11 , e75468 (2022)
Hydrophilic interaction liquid chromatography (HILIC) is better suited for the separation of polar compounds without derivatization, combining hydrophilic stationary phases and mobile phases with a high content of organic solvent [42, 58], which also enhances desolvation in the MS ion source [39]
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