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Requirements of vitamin B 12 in excess of normal (due to pregnancy, thyrotoxicosis, hemolytic anemia, hemorrhage, malignancy, hepatic and renal disease) can usually be met with oral supplementation

Some conditions that can cause this vitamin B12 deficiency include: Atrophic gastritis, an inflammation of the stomach Surgical removal of part of the stomach or intestines Conditions that affect your intestine's ability to absorb nutrients, such as Celiac disease Pancreatic insufficiency Alcoholism Acquired immune deficiency syndrome (AIDS) Some people who don't have enough of a protein called the "intrinsic factor" also have a vitamin B12 deficiency

The "Epitalon" spelling is more common in Russian and Eastern European research literature, where the compound was originally developed by Vladimir Khavinson's team at the St

Khavinson VK, Razumovsky MI, Trofimova SV, Razumovskaya AM

Temporary dose reduction during illness or significant life stress is reasonable, with resumption of escalation once circumstances normalize

The overall number of NMEs approved in 2024 (50) is on par with the volumes of the past decade