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Refrigerate after opening and use within 90 days

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Upon activation of adenosine monophosphate (AMP)-activated protein kinase (AMPK), berberine enhances insulin sensitivity, reduces hepatic glucose output, and has been shown in animal models to increase GLP-1 secretion, although this mechanism has not yet been confirmed in large human trials

Best Practices for Using Bacteriostatic Water Always use fresh needles/syringes per draw, reuse increases contamination odds

Cold solution discomfort: Let refrigerated vial warm to room temperature for ~30 minutes before injection (optional)

However, patients with severe obesity, poorly controlled type 2 diabetes, or those who still need aggressive weight reduction often do better from staying on injectable therapy because it tends to be more powerful at higher doses