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There have been reports that iris darkening is a side effect of using these types of products, though that was never their intended purpose

Levels of the enzymes glutathione peroxidase and SOD and of the nonenzymatic components of the antioxidant system including reduced glutathione, ascorbic acid, -tocopherol, lycopene, and -carotene were significantly lower in children with asthma compared with the healthy controls

doi:10.3945/ajcn.2009.27462BB

In a study aimed to establish tirzepatde influence on lipid profile [27], at 26 weeks the three dosages of the drug decreased the levels of apoB, apoC-III levels, large triglyceride-rich lipoprotein particles, and small low-density lipoprotein particles compared with both placebo and dulaglutide

It contains 0.9% benzyl alcohol that inhibits bacterial growth in the solution, supporting up to 28 days of refrigerated use per vial