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A comprehensive meta-analysis published in JAMA Psychiatry in 2025 looked at this question systematically
Incorporating milk thistle into your daily routine can be an easy way to boost your body's natural defenses
The incretin effect is very brief because it remains active 12 min after its secretion and is then inactivated by the enzyme dipeptidylpeptidase-4 (DPP-4) [7]
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However, it should not replace prescribed medications or established dietary management, and patients should consult their healthcare provider before incorporating it into their diabetes care plan
Interestingly, this effect is often dose-dependent and typically resolves once your metabolism stabilizes around week 46 of consistent use
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