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This avoids first-pass metabolism through the liver and the destructive GI environment
Int J Diabetes Dev Ctries
Glutathione S-transferase polymorphisms in research subjects with drug eruption [PMID: 14740231] Laboratory literature summary: Glutathione S-transferase polymorphisms in research subjects with drug eruption
8 Although folate deficiency may also produce a megaloblastic anemia, it is less common in the United States because of required folate fortification of enriched grain and cereal products
148,149 Etifoxine, which was developed in the 1960s, is marketed in a number of countries for treating anxiety disorders, but remains under investigation for this use in the United States