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The safety profile showed modestly elevated rates of overall side effects and drug-attributable side effect in the efinopegdutide cohort relative to semaglutide, attributable predominantly to a higher frequency of gastrointestinal manifestations [52]

Cold injection from a freshly refrigerated pen can sting more than a room-temperature injection

[1] The medication's mechanism of action involves simultaneous activation of two incretin hormone pathways

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Some people report vivid dreams or disrupted sleep on tirzepatide, but this isn't an established common side effect