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Common Side Effects and Safety Considerations Nausea is the most frequently reported adverse effect with all GLP-1 receptor agonists, occurring in roughly 44% of semaglutide users in STEP-1 and typically peaking during dose escalation

This may be treated by taking L-carnitine supplements or eating foods rich in L-carnitine (e.g., meat, poultry, fish, and dairy products), or the patient may need to stop taking valproic acid

Common adverse effects include gastrointestinal symptoms such as nausea, vomiting, diarrhea, and constipation, which typically diminish over time with dose titration

Together, these effects could lead to dangerous constipation problems, he says

By the end, you will know exactly which combination helps keep your internal defenses sharp and your recovery on track

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