Research indicates that rapid weight loss from any causeincluding pharmacotherapycan result in loss of both fat and muscle tissue
Nistic R, Cavallucci V, Piccinin S, et al
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How Water Retention and Hormones Affect Short-Term Results Glycogen depletion, cortisol elevation, and menstrual cycle hormones can shift fluid balance by 0.52 kg or more, masking fat loss on the scales without affecting actual body fat
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