placebo) Adverse events were consistent with those observed in other clinical trials for other incretins, the most common among participants treated with retatrutide (9 mg and 12 mg, respectively) being nausea (38.1% and 43.2% vs 10.7% with placebo), diarrhea (34.7% and 33.1% vs 13.4% with placebo), constipation (21.8% and 25.0% vs 8.7% with placebo), vomiting (20.4% and 20.9% vs 0.0% with placebo), and decreased appetite (19.0% and 18.2% vs 9.4% with placebo)

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It should be noted that only semaglutide injection (not oral) was compared to tirzepatide, and higher doses of semaglutide were not compared to tirzeparatide.[21] The mean A1c reduction from baseline was above 2% and weight reduction was near 10 kg (22 lbs) in tirzepatide clinical studies, exceeding current FDA-approved GLP-1 products