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95% CI, 0.29-1.24), lung cancer (HR = 0.76

Others feel off for a few days after each injection, especially in week one or two

They act through multiple mechanisms: Delayed gastric emptying, which slows the release of food from the stomach to the small intestine

It usually occurs during the first 6 months of VPA therapy and is commonly but not always preceded by minor elevations in transaminases

What to Expect in Month 2 Peak nausea: Weeks 6-8 worst for most patients, especially mornings Food aversions: Foods you loved suddenly repulsive (especially meat, coffee) Early satiety: Feel full after 3-4 bites, physical discomfort if you push it Fatigue increases: Combination of medication adjustment and reduced calorie intake Bowel unpredictability: Constipation one day, diarrhea the next Mental fog: Some patients report difficulty concentrating Research from the New England Journal of Medicine on incretin therapies shows this peak-and-resolution pattern is universal across GLP-1 and GIP agonists

Storage requirements differ by product: Ozempic and Wegovy should be stored in the refrigerator (36F to 46F) before first use