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Vomiting odds increased dramatically with an odds ratio of 9.57 compared to placebo

This may be more difficult for vegetarians or vegans

Reported tradeoff: two "shot days" per week instead of one

Kidney and cardiovascular outcomes SURPASS-4 kidney composite HR 0.58, slower eGFR decline (-1.4 vs -3.6 mL/min/1.73m2/yr), UACR -6.8% vs +36.9%

The peptide's effects on memory consolidation appear mediated through enhanced hippocampal long-term potentiation (LTP), the neurophysiological basis of memory storage, with Dihexa treatment increasing both the magnitude and persistence of synaptic strengthening

Reduced Sirt1 level/activity results in increased expression of stemness genes (i.e., NSC activatory genes) and enhanced self-renewal