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The modern GLP-1RA class evolved following identification of exendin-4, a GLP-1 analogue originally isolated from Gila monster venom [22]

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Semaglutide, originally developed for diabetes management, showed significant weight loss results in both clinical trials and real-world settings, which attracted widespread adoption

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If you have malabsorption syndrome (such as short bowel syndrome, certain bariatric surgery patients, chronic pancreatitis, or celiac disease that severely impairs nutrient uptake), you might need these injections indefinitely to prevent recurrent deficiencies

Inflammation and malnutrition in inflammatory bowel disease