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The phospholipases, activated by the toxic species, desintegrates the phopholipids, liberating the non saturated fatty acids (Halliwell and Gutteridge, 1989, resulting in the following deleterious actions of the lipidic peroxides: a) cellular membranes rupture (NA/k and Ca/Mg bombs) b) DNA mutations deoxyribonuclei acid c) Unsaturated lipids oxidation d) Chemical residues formation like the malondialdehyde e) Components engagment of the extracellular matrix, proteoglycans, collagen and elastin The lipidic peroxides possess na action power higher than the other primary toxic species of O 2 (O 2 , H 2 O 2 , OH , O 2 ), reaching further targets easily
Liposomal formulations in clinical use: an updated review
The dose starts small and is increased slowly over several weeks so the body can adjust and manage side effects such as nausea
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