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A good example of the backlash of trends is the surgical procedure of buccal fat removal, which had a real moment on social media last year only for surgeons to come out in their droves to say they no longer perform the procedure and are warning against it
NICE guidance suggests that couples should be offered fertility assessment if they have not conceived after 12 months of regular unprotected intercourse, or after 6 months if the woman is 36 years or over, or earlier if there are known fertility concerns
It should be noted that there is insufficient evidence regarding the safety of l-carnitine as a supplement during pregnancy, and although small amounts may be safe during breast-feeding, large doses should be avoided
Constipation is another common issue, reported in 21-25% of retatrutide users and a significant percentage of cagrilintide users
This phenomenon, in turn, can promote OC recurrence and chemoresistance development
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