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The GLP-1 receptor activity that suppressed hunger hormones like ghrelin fades quickly, leaving your brain's appetite centers functioning at baseline levels again
Industry publications note that advanced prior authorization forms may require weight loss documentation before continuing coverage beyond the first few months of therapy
In the STEP 1 trial extension, people who came off semaglutide regained around two-thirds of the weight theyd lost within a year
The combination with donepezil is particularly well-documented
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