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In addition, the accumulation of AGE in the tissues induces cellular oxidative stress and promotes inflammation, thus increasing the vulnerability of the target tissues [58]
10.1007/s40279-019-01148-z 50 MartignonC.PedrinollaA.RuzzanteF.GiuriatoG.LaginestraF
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The addition of phenformin, a Complex I inhibitor, caused the oxphos reliant cells to switch to a glycolysis signature, highlighting the plastic nature of the oxphos reliant cells
7.3 NETosis-related tubular injury NETosis is a specialized form of neutrophil cell death where neutrophils extrude their nuclear chromatin and granular proteins to form neutrophil extracellular traps (NETs) (218)
Particularly when its chronic, patients often wind up in kidney failure and on dialysis, which has basic scientists and physicians alike looking for better interventions
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