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More serious but rare side effects require immediate medical attention
In addition, human-interest senolytic dosing is typically pulsed/intermittent (a few consecutive days per cycle), so the continuous once-daily-for-16-weeks schedule shown here diverges from the typical senolytic paradigm and should be read as illustrative, not validated
Key points
For severe, persistent abdominal pain (especially if radiating to the back) with vomiting, seek urgent same-day medical attention or go to A&E, as this could indicate pancreatitis, a rare but serious potential side effect
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Loss of either the ATF6 or the IRE1 pathways sensitizes animals to ER stress-induced liver steatosis, metabolic dysregulation and mortality (140)
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