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Translational studies have supported a role for GLP-1RA-mediated slowing of gastric emptying in very early improvements in glycemia [16], but such studies have not been completed with tirzepatide
Nausea and diarrhea occur in 25%50% of patients early in treatment
It mimics the GLP-1 hormone, which is secreted by the gut post-meal to regulate appetite and metabolism
Carnitina, Wikipedia.
The question of whether weight loss on top of great medical therapy can lower events has been answered, and the effect is impressive
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