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Vitamin B12 shots are the most common way to prevent or treat a deficiency

In the UK, the standard NHS regimen for B12 deficiency without neurological involvement is hydroxocobalamin 1mg IM three times a week for two weeks

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The treatments were done in a very timely manner

We first observed, in a previously published bulk RNA-seq dataset of MEFs undergoing in vitro reprogramming 40 , that Mtr and Cd320 were upregulated soon after OSKM induction, remaining high during the early and middle phases of reprogramming, ultimately stabilizing to levels above those measured in MEFs (Extended Data Fig