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Why brain-based GLP-1 activity matters clinically: It helps explain the appetite-suppressing effects of GLP-1 receptor agonist medications It may contribute to neuroprotective mechanisms being investigated in neurodegenerative diseases It potentially influences cognitive processes and mood regulation, though human evidence remains limited It provides insight into the gut-brain axis and metabolic-neurological interactions Understanding GLP-1's cerebral actions has become particularly relevant as GLP-1 receptor agonistsoriginally developed for type 2 diabetesare now also licensed for weight management in the UK (NICE TA875, TA664)
Yoon KH, Kang J, Kwon SC et al (2020) Pharmacokinetic and dose-finding studies on efpeglenatide in patients with type 2 diabetes
Most patients notice improved blood sugar control and changes in appetite within a few weeks
Talib, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
Chen, T
2018) using an online software tool for method comparison and bias detection (Bahar et al
