GHK-Cu (Glycyl-L-Histidyl-L-Lysine copper complex, also known as Copper Tripeptide-1) is a naturally occurring tripeptide bound to a copper ion (Cu)
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The foundational research here traces back to Loren Pickart, whose decades of work culminated in a widely cited 2018 review in the International Journal of Molecular Sciences documenting that GHK-Cu modulates the activity of thousands of human genes tied to tissue remodeling, antioxidant defense, and inflammatory regulation