semaglutide fat vs muscle loss Long-term weight effects of in obesity without diabetes in the SELECT trial Semaglutide 2.4 mg and lean

Clinical research has extended this concept by evaluating cagrilintide-semaglutide treatment in adults with overweight or obesity and type 2 diabetes, providing evidence that combined pathway engagement can improve both weight-related and glycemic outcomes [6]

This has been observed across the GLP-1 class including semaglutide and liraglutide and it's the reason these medications carry a boxed warning about medullary thyroid carcinoma in the US

That means someone losing 30 pounds could lose 13 to 14 pounds of muscle if they do not actively protect it through proper nutrition on semaglutide

ACKNOWLEDGMENTS None NOTES Fig

Practical Strategies: Keep the Microbiome Moving Heres how we can support gut resilience during GLP1 therapy: 1

doi:10.1016/j.jds.2022.11.016 Pressman AH, Buff S