Serious or fatal hepatotoxicity may be preceded by non-specific symptoms such as malaise, weakness, lethargy, facial edema, anorexia, and vomiting
Triple receptor agonists have the potential to further bridge the efficacy gap in WL between BS and the currently approved obesity pharmacotherapies, with the added potential for other synergistic metabolic benefits, such as improving glycaemia in people with T2D, and treating or preventing MASLD/MASH
The bitter taste receptor has been demonstrated to affect the release of many gut hormones, primarily glucagon-like peptide, which is implicated in the process of regulation of glucose homeostasis
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Patients should not independently stop therapy without discussing the plan with their care team, because abrupt interruption may affect glucose control or other treatment goals
This warning is based on animal studies showing an increased incidence of thyroid tumors in rodents exposed to GLP-1 receptor agonists