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[10] CagriSema combination (late-stage investigational): phase 3 trial results are published and the combination is under regulatory review, but readers should treat it as an investigational product, not an established standard of care

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2017 study reported improvements in aged mice that were sustained through the observation period, suggesting that senescent cell clearance produces durable benefits once senescent cells are eliminated, their pro-inflammatory SASP burden is removed, allowing tissue recovery that persists beyond the treatment window