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For weight management medications, NICE guidance specifies different stopping rulesfor example, Wegovy treatment should be reviewed after 6 months, and Saxenda should be discontinued if less than 5% weight loss is achieved after 12 weeks at the maintenance dose
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SundstromLMyhreSSundqvistMAhnmarkAMcCoullWRauboPet al
10.1038/s41371-019-0248-1 30
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The gut bacteria make more GLP-1, which then activates the same receptors that medications target
In addition to these conventional sites of mitochondrial ROS generation, it has been recently reported that the branched-chain 2-oxoacid dehydrogenase (BCKDH) complex in mitochondria can produce superoxide and H 2 O 2 at higher rates than complex I from mitochondria (Quinlan et al., 2014)
