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Product-related impurities in clinical-grade recombinant AAV vectors: Characterization and risk assessment
They included the metabolism of valine/leucine/isoleucine and cysteine/glutathione
Spadaro, A., Scott, K
It covers the common ones you will almost certainly encounter, the uncommon ones worth watching for, and the rare but serious events that require immediate attention
The jurys still out on these since some studies show a smaller insulin response while others show no meaningful effect (like this study)
All three use fatty-acid conjugation to bind albumin and extend half-life
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