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3 However, the latest American Diabetes Association and Kidney Disease: Improving Global Outcomes guidelines now recommend glucagon-like peptide-1 (GLP-1) receptor agonists, with or without metformin, as initial pharmacotherapy for patients with type 2 diabetes who are at high risk for cardiovascular disease, heart failure, or CKD
A meta-analysis found that one type of GLP-1 medication may be more effective than others
Pharmacology and Mechanism GLP-1 receptor agonists mimic the endogenous incretin hormone GLP-1
How Dose Progression Affects Tolerance And Side Effects The slow dose progression is a deliberate strategy to improve tolerance and manage the side effect profile of these medications
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