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Adrenal Gland Disorders: These can disrupt hormonal balance and trigger overproduction of melanin

Polyphenols contain hydroxyl groups capable of scavenging ROS and chelating redox-active metals resulting in the suppressed ROS (hydroxyl radicals) via Fenton chemistry or other mechanisms (Simunkova et al

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The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling

These are hard deposits made of minerals and salts that build up

Neurological deficits in mice with profound biotinidase deficiency are associated with demylination and axonal degeneration