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In addition to PanNETs, duodenal NETs show high prevalence of GLP- 1R expression
Translational Gastroenterology and Hepatology, 3
As tolerance develops, symptoms often diminish after 4-8 weeks
Retatrutides structure is optimized for tight albumin binding while still allowing it to activate all three target receptors
These modifications include an Ala8Aib amino acid substitution and attachment of a C18 fatty diacid side chain at Lys26 via a linker that promotes albumin binding, significantly prolonging circulation time compared to native GLP-1
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