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Overall, the evidence base is promising, the safety profile is encouraging, and clinical outcomes especially under properly designed protocols can be significant

10.1007/s13244-017-0572-3 142 TshionyiM.ShayE.LundeE.LinA.HanK

Doses of folic acid greater than 0.1 mg per day may result in hematologic remission in patients with vitamin B 12deficiency

Those with pre-existing cardiac conditions or on medications affecting potassium levels may require closer monitoring

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Despite these similarities, meaningful differences exist that should inform your choice between them