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In 2025, VMAIL reported that the American Optometric Association (AOA) had released a clinical report by their evidence-based optometry committee warning of some serious ocular complications associated with GLP-1 receptor agonists, including exacerbation of age-related macular degeneration, progression of diabetic retinopathy and the rare but serious onset of NAION

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Investigational Drug Status "Investigational" means the drug is being studied but hasn't been proven safe and effective to the FDA's standard

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Nat Rev Endocrinol (2020) 16(3):13546

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This is more common for people with diabetes or when calorie intake drops because of the medication

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Clinical trials don't require a prescription but do require screening and enrollment

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