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doi:10.1016/bs.apha.2018.12.004 Su W, Zhang Y, Zhang Q, et al
Murto T, Skoog Svanberg A, Yngve A, et al
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In the Mthfr +/ and Mthfr / mice, the plasma total homocysteine levels were 1.6- and 10-fold higher, respectively, than the wildtype controls
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The first-round optimization led to Compound 70 , which contains a 5-methyl-1-phenyl benzimidazole moiety and exhibited an excellent increase in potency (IC 50 : 52 nM)
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