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Hypothalamic-pituitary-adrenal and hypothalamic-pituitary-gonadal axes: sex differences in regulation of stress responsivity

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Adverse Effects: Hypertension Peripheral ischemia or necrosis (with prolonged use) Reflex bradycardia Arrhythmias (rare) Key Monitoring Parameters: Continuous blood pressure (invasive or non-invasive) Urine output (for perfusion adequacy) Cardiac rhythm and lactate levels Pharmacists Note: Avoid abrupt discontinuation gradually taper the dose