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Patients experiencing frequent hypoglycemia, recent dosage adjustments, or poor metabolic control may be temporarily deferred regardless of their specific medication regimen
Cunnane SC, Crawford MA (2014) Energetic and nutritional constraints on infant brain development: implications for brain expansion during human evolution
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Because the nutrients are non-toxic, any agitation usually subsides quickly when they are discontinued
The pyruvate is then oxidized by the pyruvate dehydrogenase complex (PDHc) and the resulting acetyl-CoA can enter the TCA cycle
This has resulted in extensive research into developing PFKFB3 inhibitors [reviewed in detail in (215)]
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