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Glutamine in cancer cells plays critical and diverse roles by providing not only a source of nitrogen for amino acid and nucleotide biosynthesis but also a source of carbon to replenish the tricarboxylic acid (TCA) cycle and lipid biosynthesis pathways
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PubMed DOI Seiwerth S, Sikiric P, Grabarevic Z, et al
doi: 10.1007/s12275-013-3168-8 70 RahnamaM.MacleanP.FleetwoodD
Available online at: (Accessed November 20, 2025)
This activity mediates the differentiation of CD4 + T cells into Th1 and Th17 subtypes, promoting the production of inflammatory factors such as IFN- and IL-17, and shifting their metabolic profile from oxidative phosphorylation to glycolysis [392]
Carbonetto P, Stephens M
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