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It was found that CB-839 could synergize with other anticancer drugs to exert beneficial therapeutic effects, and KRAS mutation led to enhanced glucose and glutamine metabolism in ovarian cancer cells, which was better inhibited by the combination of metformin and CB-839 [32]
A.DubrulleJ.MoensC
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State-of-the-art Ulcerative Colitis Treatment By Kim Crawford, M.D
When the cellular environment is under oxidative stress, Fe 3+ acts as a catalyst to drive the non-enzymatic oxidation of dopamine, leading to the formation of dopamine-quinone derivatives that can bind iron to form iron-dopamine-quinone complexes
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