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thelancet.com/journals/lance ACHIEVE 2: in metformintreated T2D, oncedaily oral #orforglipron lowered HbA1c more than #dapagliflozin (up to ~1.6% vs ~0.8% at 40 weeks) and produced greater weight loss (~57% vs ~23%), with the expected GLP1 GI tolerability profile but low hypoglycemia and similar serious events
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The trial was sponsored by the drug manufacturer Novo Nordisk and published in the New England Journal of Medicine
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It is an off-label practice to potentially reduce the monthly expenses of Ozempic and Wegovy, mitigate the severity of gastrointestinal side effects, and prevent weight regain in the maintenance phase
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