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Irisin activates SIRT1 to deacetylate PGC-1 and improve mitochondrial function To further investigate the biological effects of irisin in regulating PGC-1 through SIRT1, we employed co-immunoprecipitation to purify the SIRT1 downstream target protein, PGC-1 and assessed its acetylation levels

Inflammation and oxidative stress can also damage our mitochondria, which produce the energy inside our cells that powers life itself

L-Carnitine may improve exercise performance and recovery due to its antioxidant and anti-inflammatory properties shown to reduce exercise-induced muscle damage

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Transgenic mice: fat-1 mice convert n-6 to n-3 fatty acids