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[5] Increased levels of pyroglutamic acid in the blood, leading to excess in the urine (5-oxoprolinuria), can occur following paracetamol overdose, as well as in certain inborn errors of metabolism, causing high anion gap metabolic acidosis
Only through these approaches can the current gapclear mechanisms but poor clinical translationbe overcome, advancing ferroptosis-targeted therapy as a strategy to improve neurological outcomes in TBI patients