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Melatonin reprograms the effector state of activated ILC2s To further dissect the effects we had observed, we isolated aILC2s from IL-33 challenged BALB/c mice ( Supplementary Figures 2 ) and performed bulk RNA sequencing, comparing the transcriptome of vehicle and melatonin treated cells ( Figure 5A )
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ISSN 1562-2975
Of these genes, EtOH feeding up-regulated Fads1 and down-regulated Acox1 genes in WT mice, a result in agreement with the observed increase in total TG content
The monitoring of GSH/GSSG ratio and the quantification of GSSG in biological samples are essential for evaluating the redox and detoxification status of cells and tissues in relation to the protective role of glutathione against oxidative and free-radical-mediated cell injury
doi: 10.1186/s12944-020-01342-3 137 O'NeillLAKishtonRJRathmellJ
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