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Taken together, these results suggest that the vagus nerve is involved in a key GLP-1 signal transduction pathway that modulates locomotor activity in gut microbiota-deficient mice

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Equally important, pre-procedure gastric ultrasound identified helped identify patients at risk of aspiration and helped guide decision making

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Toward More Tailored Dosing Strategies While the panacea of individualised dosing regimens might represent a leap too far in terms of complexity, the opportunity does exist for pharmaceutical companies to implement a more tailored approach when it comes to dosing, arriving at a more delicate balance of drug exposure, bioavailability, efficacy and safety based on the characteristics of certain patient cohorts

At week 26, treatment with TOUJEO provided a mean reduction in HbA1c that met the prespecified noninferiority margin compared to LANTUS (Table 5)