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Caffeine While moderate caffeine consumption may have some health benefits, excessive intake can reduce glutathione levels

Increasing a dose too quickly or restarting the medication after an extended break can cause or increase nausea

Reagents All chemicals were purchased from Sigma-Aldrich, unless indicated otherwise

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Reconstitution requirements add another variable

Acute toxicity studies have failed to establish a lethal dose even at very high concentrations in rodents, a finding reported by the Sikiric group and referenced in several reviews